- Depression: In the 1970s, Italian researchers found that patients being treated with SAMe for schizophrenia were experiencing less depression. In tests and trials since that time, results have shown SAMe to be equal, or superior, to tricyclic antidepressants. Not only is it more effective, it works faster, and without significant side effects.
- Fibromyalgia: SAMe has been shown to improve symptoms of pain, fatigue, morning stiffness, and mood in patients with fibromyalgia.
- Liver Disease: SAMe is highly concentrated in liver tissue. Clinical studies indicate SAMe treatment can reverse hepatic glutathione depletion in patients with liver disease; improve survival or delay liver transplantation in patients with alcoholic liver cirrhosis; and reduce biochemical parameters of intrahepatic cholestasis, such as bilirubin and bile salts, and subjective symptoms, such as pruritis, fatigue, and general discomfort.
- Osteoarthritis: SAM was found to have a beneficial effect on osteoarthritis while it was being used to treat patients for mood disorders. The Arthritis Foundation's Guide to Alternative Therapies notes that "SAM is a promising treatment worth trying for pain relief". A significant amount of research supports the use of SAMe in treating osteoarthritis. SAMe has been shown to be at least as effective as NSAIDs, if not more so, without causing the gastrointestinal side effects associated with NSAID use.
- Migraine: Studies suggest that SAMe may help in the treatment of migraines with less side effects than current treatments.
- ADD: Doctors are currently studying the effects of SAMe on Attention Deficit Disorder. They theorize that with the calming, anti-stress effects, SAMe may be able to bring some measure of relief from ADD symptoms.
- Asthma: Since stress is often a major factor in the frequency of asthmatic attacks doctors believe that SAMe's stress reducing properties may help in preventing asthma attacks.
- Parkinson's disease: Studies are still being conducted on the possible benefit of SAMe in the treatment of Parkinson's disease.